December 16, 2015
If you need a short answer, it would be “Whatever you like”.
Both MySQLi and PDO have their advantages:
PDO will work on 12 different database systems, where as MySQLi will only work with MySQL databases.
So, if you have to switch your project to use another database, PDO makes the process easy. You only have to change the connection string and a few queries. With MySQLi, you will need to rewrite the entire code – queries included.
Both are object-oriented, but MySQLi also offers a procedural API.
Both support Prepared Statements. Prepared Statements protect from SQL injection, and are very important for web application security.